Molecular mechanisms of neurodegenerative diseases: Lecture essays

Authors

Mikhail A. Paltsev, Igor M. Kvetnoy, Victoria O. Polyakova, Ekaterina M. Paltseva, Samir U. Mursalov, Usman K. Mursalov, Natalia S. Linkova, Russell J. Reiter

Synopsis

In the monograph, various hypotheses of molecular and cellular mechanisms of development of neurodegenerative diseases are analyzed in detail, namely Alzheimer’s disease, Huntington's disease and Parkinson’s disease. From the perspective of neuroimmunoendocrinology which is an integral biomedical science, the prospects of using signal molecules synthesized in the central nervous system as biological markers for optimization of life-time diagnostics and targeted therapy of these diseases are considered. A modern methodology for studying the molecular mechanisms of neuronal death is described, which can be used to develop modern neuroprotective medications. Particular attention is paid to the authors’ pioneering research on the use of tissues available for biopsy (blood lymphocytes and buccal epithelium), for the life-time early diagnosis of neurodegenerative diseases. The book was based on lectures given by the authors in various medical and biological research university centers in Russia, Kazakhstan, Spain, Belgium, Portugal, and the United States.

The book is of interest to a wide range of specialists such as neurobiologists, neurologists, pathologists, histologists, psychiatrists, geneticists, researchers in the field of cellular and molecular biology.

 

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Author Biography

Mikhail A. Paltsev

Lomonosov Moscow State University

Academician, Chief Academic Secretary of the Presidium of the Russian Academy of Sciences. The winner of USSR State Prize and the Prizes of the Government of the Russian Federation in the field of science and technology, the Prize of the Russian President and the Russian Federation Government Prize in the field of education, Sarkisov, Gulevich and Strukov nominal Prizes of the Russian Academy of Medical Sciences. Honorary Member of the Russian Academy of Education. Honorary Professor of Lomonosov Moscow State University. Doctor of Medical Scienses, Professor of Pathology.

Igor M. Kvetnoy

Scientific Research Institute of Obstetrics and Gynecology by D.O.Otta of the Russian academy of medical sciences

Honored Scientist of Russian Federation. The winner of the Prize of the Government of the Russian Federation in the field of science and technology, and of the Pearse Prize of the Royal Microscopical Society of the Great Britain. Doctor of Medical Sciences, Professor of Pathology. The Head of the Department of Pathology at the Ott Institute of Obstetrics, Gynecology and Reproductology, and of the Department of Cell Biology and Pathology at the St. Petersburg Institute of Bioregulation and Gerontology.

Victoria O. Polyakova

Scientific Research Institute of Obstetrics and Gynecology by D.O.Otta of the Russian academy of medical sciences

The winner of the Prize of the Government of the Russian Federation in the field of science and technology, and of L.Euler Award of the Government of St. Petersburg and St. Petersburg Scientific Center of the Russian Academy of Sciences. Doctor of Biological Sciences, Professor of Cell Biology, Cytology and Histology. The Head of the Laboratory of Cell Biology at the Ott Institute of Obstetrics, Gynecology and Reproductology, and of the Laboratory of Immunology of Aging at the St. Petersburg Institute of Bioregulation and Gerontology.

Ekaterina M. Paltseva

B.V. Petrovsky Russian Surgery Research Center

The winner of the Prize of the Government of the Russian Federation in the field of science and technology. Doctor of Medical Sciences, Associate Professor of Pathology. The Head of the Division of Pathology II (Immunohistochemistry) at the B.V. Petrovsky Russian Surgery Research Center.

Samir U. Mursalov

St. Petersburg Institute of Bioregulation and Gerontology

Ph.D., M.D. Senior Researcher at the Department of Cell Biology and Pathology at the St. Petersburg Institute of Bioregulation and Gerontology.

Usman K. Mursalov

Azerbaijan State Medical University

M.D. Psychiatrist-Consultant of the Department of Psychiatry at the Azerbaijan State Medical University (Republic of Azerbaijan). Colonel of medical service (with transfer to the reserve was the Chief psychiatrist of the North-West Military District of the Russian Federation).

Natalia S. Linkova

Peter the Great St. Petersburg Polytechnic University

Senior Researcher of the Laboratory of Biogerontology at the St. Petersburg Institute of Gerontology and Bioregulation, Associate Professor (Medical Physics) of the Laboratory of Molecular Neurodegeneration at the Peter the Great St. Petersburg Polytechnic University. Doctor of Biological Sciences.

Russell J. Reiter

University of Texas

Doctor of Biology, Professor of Neuroendocrinology of the Department of Cellular and Structural Biology at the Health Science Center, University of Texas, San Antonio, United States. Doctor Honoris Causa of three European Universities. Dr. Reiter has received numerous awards for his research including the A. Ross McIntyre Gold Medal (USA), the US Senior Scientist Award (Germany), Lezoni Lincee Award (Italy), and Aaron Lerner Award (USA). The Thomson’s Institute lists him as one of the top 100 scientists in the world in terms of frequency of citation in the fields of cell biology and biochemistry. He is the member of the editorial boards of 26 international scientific journals.

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Published

2018 February 2

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Details about this monograph

Co-publisher's ISBN-13 (24)

978-5-906648-10-5

Date of first publication (11)

2016-02-14