Цинк и рак предстательной железы
Краткое описание
В книге впервые представлена систематизация количественных морфометрических данных о возрастных изменениях относительных объемов основных гистологических структур предстательной железы, а также сведений о возрастных изменениях содержания цинка в ткани железы и простатической жидкости (соке), что выявило новые аспекты нормальной физиологии и метаболизма цинка в предстательной железе. Большое внимание уделено изменению содержания цинка в ткани и соке железы при ее доброкачественной гиперплазии и злокачественной трансформации. Обнаруженные изменения легли в основу новых способов дифференциальной диагностики этих заболеваний, в которых уровень цинка определяется в материале пункционной биопсии или в образце сока методом рентгеновской флуоресценции. Рассмотрены возможности неинвазивного in vivo определения концентрации цинка в предстательной железе. На основании данных о многократном возрастном увеличении содержания цинка в железистом эпителии сделано заключение о роли избыточной внутриклеточной концентрации этого элемента в этиологии гиперплазии и рака простаты, а также сформулирован ряд аргументированных рекомендаций по профилактике этих заболеваний.
Издание предназначено врачам-патофизиологам, биохимикам, медицинским физикам, урологам, онкологам, а также широкому кругу лиц, интересующихся вопросами профилактики, диагностики и лечения доброкачественной гиперплазии и рака предстательной железы.
Главы
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Глава 1. Анатомия, морфология и физиология предстательной железы
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Глава 2. Ядерно-физические методы определения цинка
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Глава 3. Возрастные изменения содержания цинка в предстательной железе
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Глава 4. Содержание цинка в ткани предстательной железы при патологических состояниях
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Глава 5. Содержание цинка в соке предстательной железы при патологических состояниях
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Глава 6. Скрининг по выявлению рака предстательной железы
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Глава 7. Влияние облучения на концентрацию цинка в соке предстательной железы
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Глава 8. Референтные значения содержания цинка в ткани предстательной железы
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Глава 9. Референтные значения концентрации цинка в соке предстательной железы
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Глава 10. Метрологическое обеспечение определения концентрации цинка в образцах ткани и сока предстательной железы
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Глава 11. Возможности in vivo определения содержания цинка в предстательной железе человека, исследованные в ИМР АМН СССР
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Глава 12. Зарубежный опыт использования цинка в качестве онкомаркера рака предстательной железы
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Глава 13. Роль цинка в этиологии доброкачественной гиперплазии и рака простаты, а также в способах профилактики и лечения этих заболеваний
Скачивания
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