Митохондриальная дисфункция: роль в фетальной и перинатальной патологии
Краткое описание
Монография посвящена роли ключевых клеточных органелл — митохондрий в развитии фетальной и перинатальной патологии. Проанализирована роль митохондрий в поддержании нормальной функции плаценты во время беременности.
Подробно описаны изменения структурно-функциональной деятельности митохондрий при различных заболеваниях, возникающих в фетальном и перинатальном периодах — важных стадиях онтогенеза человека. Приведены конкретные примеры связи накопления поврежденных митохондрий с широким спектром патологии — от неврологических нарушений до заболеваний опорно-двигательного аппарата, развивающихся в перинатальном периоде и манифестирующих в более зрелом возрасте. На основании многочисленных данных литературы и собственных исследований убедительно показано, что верификация митохондрий в качестве морфофункционального «субстрата» фетальной и перинатальной патологии открывает широкие перспективы для разработки персонифицированных таргетных подходов к профилактике и лечению заболеваний.
Издание рассчитано на широкий круг врачей и биологов, работающих в области фундаментальной и клинической медицины, — молекулярных биологов, цитологов, генетиков, патофизиологов, акушеров-гинекологов, перинатологов, педиатров и других специалистов.
Главы
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Глава 1. Митохондрии: структурно-функциональная организация, биогенез, роль в жизнедеятельности клеток
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Глава 2. Митохондрии: методология молекулярно-микроскопического исследования
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Глава 3. Митохондриальные дисфункции и перинатальная патология: общий пейзаж
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Глава 4. Митохондрии и функции плаценты в норме и патологии
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Глава 5. Митохондрии и фетопатии
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Глава 6. Митохондрии и неонатальная патология легких
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Глава 7. Митохондрии, метаболизм миокарда и кардиомиопатия
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Глава 8. Фетальная и перинатальная невропатия: роль митохондрий
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Глава 9. Митохондрии, окислительный стресс и опухоли плода
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Глава 10. Митохондрии и свободные радикалы в перинатальных повреждениях мозга
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Глава 11. Митофагия как мишень при перинатальной патологии
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Глава 12. Роль эстрогенов при дисфункции митохондрий
Скачивания
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